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Vitamin B12 (cobalamin) is essential for: Red blood cell production DNA synthesis Nervous system function Energy metabolism B12 deficiency is common in the UK, especially among people following vegetarian or vegan diets, those over 50, or individuals with gastrointestinal conditions affecting absorption (e.g., coeliac disease, Crohns, IBS)

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In 2015, Papakyriakou et al

Anticipate some variation, with a few advantages persisting longer

52,53 Additional examples of bioactive factors used in pre-clinical and clinical trials are included in Table 1, all of which suggest that tailored growth factor delivery may improve cartilage repair in aged patients