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Appetite suppression, delayed gastric emptying, and altered absorption are all considered plausible contributors to increased micronutrient deficiency risk

Animal studies show that giving low doses (1-10mcg/kg) of melatonin speeds up intestinal transit times, but higher doses (100-1000mcg/kg) slow transit time significantly.[ref] IBS is often accompanied by increased transit time (diarrhea) or slowed transit time (constipation)

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10.2174/1573404813666161221164810 41 PangY.BaiG.ZhaoJ.WeiX.LiR.LiJ.et al (2022)

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