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CLIC1 is an intracellular channel whose overexpression in cancer correlates with increased matrix stiffness (through the Wnt/-catenin/TCF4 signaling pathway) and altered glycolytic metabolism (Warburg effect), favoring tumor proliferation

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Small molecule metabolite extraction strategy for improving LC/MS detection of cancer cell metabolome

B 0 is the baseline motor score, E max is the maximum inhibitory effect, Cp is the apomorphine plasma concentration predicted by the PK model, Ce is the drug concentration at the site of action, EC 50 is the drug concentration that causes 50% of the maximum effect, g is the Hills sigmoid coefficient, and k e0 is the first-order plasma-effect-site equilibration rate constant

Alzheimer, Parkinson ve dier nrodejeneratif hastalklarda glutatyon seviyelerinin dk olduu gzlemlenmitir