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Owing to donor-to-donor variability associated with human samples, we repeated this protocol in additional sets of islets from humans that spanned a range of BMI, age and HbA1C%, and included donors of both sexes (Extended Data Table 2)

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102,319,320,321 A single-center double-blind, randomized, parallel placebo-controlled study found that uric acid reduction slowed the decline of glomerular filtration rate in patients with stage 3 and 4 CKD

J Diabetes Metab Disord 24, 160 (2025)

In fact, oxidative stress is increasingly recognised as a contributing factor in stone formation, and glutathione's antioxidant function may have a modest protective effect on renal epithelial cells that are vulnerable to crystal adhesion