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As a result, the physiological regulation of Keap1-Nrf2 is lost, and free NAPQI reacts with protein sulfhydryl groups to form APAP adducts (Figure 1)

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Oxidative stress plays a vital role in the development of obesity and dyslipidaemia, insulin resistance and diabetes, hypertension via various mechanisms associated with ROS-led inflammatory response and endothelial dysfunction

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