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MECHANISTIC SPECULATION: WHAT THE FRAMEWORK CLAIMS Mechanistic speculation = inferring possible antiaging effects from models, genes, and expression patterns rather than from clinical outcomes

Blood work provides objective data that subjective symptom assessment cannot

Insulin increases Na(+)-H+ exchange activity in proximal tubules from normotensive and hypertensive rats

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These figures are striking on both sides, but they come from two different trials with different lengths and patient populations and were never measured against each other so they describe each drug individually, not a winner

These conditions have also been associated with immune dysregulation, inflammation/oxidative stress and mitochondrial dysfunction