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Phase 2: Maintenance (Every Other Day) Most Important Goal: Sustain results with the lowest effective dose

Among the 3,532 participants in the FLOW trial, 19.2% (678 individuals) had heart failure at baseline, with 47.9% classified as having HFpEF, 18.1% as having heart failure with reduced ejection fraction (HFrEF), and 33.9% with unknown status

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consider withholding SGLT-2i if volume depletion risk is high

TRIUMPH-2 will support a potential combined obesity-and-diabetes indication