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GLP-1 receptor agonists are associated with reduced ascending aorta dilatation in patients with type 2 diabetes: a prospective study
L-citrulline is first converted to L-arginine in the kidneys, which then produces nitric oxide
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doi: 10.1016/j.gtc.2005.05.005 151 RoberfroidM.GibsonG
Whether mindfulness-based or other non-pharmacological approaches can meaningfully replicate part of this effect is a genuinely promising but still early area of research, worth watching rather than treating as settled