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Patients with a history of pancreatitis, severe gastrointestinal disease, or thyroid cancer are typically not candidates

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Unresolved questions and future directions Currently, despite promising prospects in preclinical models, targeting glutamine metabolism faces challenges in clinical trials due to inherent heterogeneity in glutamine metabolism within tumor cells and immune cells, as well as its complex impact on immune responses

Neuroendocrine signaling intersections: GHRH-axis signaling is sometimes studied alongside neurochemical pathways linked to sleepwake regulation in model organisms, supporting exploratory research into hormoneneurotransmitter relationships

Filipovic MR, Koppenol WH

Its still an experimental synthetic peptide with limited human study results