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Reduced atherosclerosis in MyD88-null mice links elevated serum cholesterol levels to activation of innate immunity signaling pathways

This condition creates an opportunity to form mtDNA-protein crosslinks mediated by ROS, which increases mitochondrial fission and exacerbates mtDNA damage (Caston and Demple, 2017

doi: 10.1055/s-00000041 214 HoshinoKTakeuchiOKawaiTSanjoHOgawaTTakedaYet al

In this state, microglia often assume an amoeboid form characterized by fewer processes and a reduced surveillance range [31]