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Don, resist hyperuricemia and acute gouty arthritis activity in animal models

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Under hypoxic conditions, HS regulates HIF-1 through dual pathways: it reversibly reduces cellular oxygen consumption to accelerate VHL-mediated HIF-1 ubiquitination and degradation, while decreasing HIF-1 stability to inhibit downstream genes (e.g., VEGF, GLUT1) when mitochondrial function is preserved (Kai et al., 2012)

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10.1111/j.1743-6109.2010.01884.x 29 FitchW