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However, spermatogonia loss was higher than Sertoli and Leydig cell loss after busulfan exposure (39) and because the status of spermatic germ cells depends on Leydig and Sertoli cells function, apoptosis of these supporting cells can also endanger vitality of spermatic germ cells (46)

This important factor needs to be taken into consideration during patientphysician conversations when evaluating treatment options, enabling a patient-centered and personalized approach to disease management

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