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doi: 10.1152/physrev.00034.2006 20 BornerTDe JongheBCHayesMR

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The schistosomicidal activities of PZQ and of potassium antimonial tartrate, a drug used in the past for schistosomiasis and a TGR inhibitor, are reduced in immunosuppressed mice 65 , indicating a crucial role of the host immune system in the mechanism of action of schistosomicidal agents in vivo

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Increased signaling of the classical and the alternative RAS may contribute to the effects observed in our study [6, 36, 41]