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In one study, AOD-9604 was shown to decrease the production of pro-inflammatory cytokines, such as tumor necrosis factor-alpha (TNF-) and interleukin-1 beta (IL-1), in rats with rheumatoid arthritis

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Research consistently shows that combining GLP-1 agonists with progressive resistance training and protein intake of 1.6 to 2.2 grams per kilogram of body weight significantly reduces lean mass loss