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Disease-modifying therapies for ATTR-CM can be classified into three main strategies: 255 (1) stabilizing TTR tetramers to inhibit dissociation, (2) suppressing hepatic TTR synthesis, and (3) promoting the clearance of amyloid deposits via antibody-driven phagocytosis (Fig

A patient carrying certain GLP1R or GIPR variants may show stronger appetite suppression or metabolic adaptation, but individual outcomes depend on adherence, diet, exercise, and overall health status

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The growing interest in GLP-1 stems partly from the success of GLP-1 receptor agonist medications (such as semaglutide and liraglutide) in treating type 2 diabetes and obesity