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Description

In the liver, retatrutide has similar efficacy to naturally occurring glucagon in evoking glucose production

It is administered once weekly by subcutaneous injection, with doses escalated gradually from a low starting dose up to 12 mg weekly in Phase 2 trials

Only 13 states provided coverage as of January 2026, down from 16 states in 2025, likely reflecting the significant costs of coverage and recent state budget challenges and federal funding cuts

Imataka, K