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Hum Reprod Update 2019

For many people, this happens because the body gets used to the medicines active ingredient, semaglutide, so over time, it may not work as well

International Journal of Molecular Sciences, 24 (13), 10449

Triple agonists including retatrutide show exceptional promise based on remarkable weight loss and liver fat normalization in early trials, with dedicated MASH histology studies ongoing

Newer agents, notably semaglutide and tirzepatide, offer very potent, long-acting effects on weight loss

They cited unverified risks and uncertainties regarding content and quality as the primary reasons to avoid them