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While ETC is the source of superoxide, the existence of mitochondrial NO synthase (mtNOS) that provides the NO required to form peroxynitrite is controversial

They include psychotherapy, medication, and lifestyle changes, often utilized in combination

doi: 10.1007/s00125-018-4789-6 37 DruckerDJ

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Funding The study was supported by Health and Medical Research Fund (project number 16172921)

Weight loss and lifestyle changes have proven to be effective in restoring menstrual regularity and reproductive function, improving hyperandrogenism, glucose and lipid metabolism, and insulin sensitivity, thus reducing cardiovascular risk in women with PCOS [18,19,20]