Gut microbiota changes in PD can contribute to -syn pathology propagation, modulate neuroinflammation, influence drug metabolism, and exacerbate autonomic symptoms
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However, as reported concentrations of GSH are in the range of 0.2 mol/l in CSF and 1 mmol/l in brain tissue, 7 GSH in CSF would not appreciably change the MRS determination of GSH in brain tissue
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The effects of gut-derived GLP-1 secretion are considered to be more significant in preventing weight gain rather than directly inducing weight loss, based on findings from animal studies on GLP-1 releasers including gastrointestinal distention [53] and d-allulose [54]
Research Behind Drugs For Obesity Wins Prize