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doi: 10.1002/osp4.619, 106

Vascular, but not luminal, activation of FFAR1 (GPR40) stimulates GLP-1 secretion from isolated perfused rat small intestine

For example, the results of a study that used actuarial methods to compare the estimated lifetime CV, kidney and mortality benefits of the combination of an SGLT2i plus a GLP-1 RA plus finerenone versus conventional therapy (a RAAS inhibitor plus traditional risk factor control) found that the triple combination has the potential to afford more relevant gains in CV and kidney event-free and overall survival in patients with CKD and T2D versus conventional therapy alone [50]

In one study combining a certain GLP-1 medication with behavioral modifications, more than half of the participants lost 15% of their body weight, and about a third lost 20%

then dose mg concentration = volume (mL)