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Its encoded protein, circINSIG1-121, recruits the CUL5-ASB6 E3 ligase complex to promote K48-linked ubiquitination of INSIG1a key regulator of cholesterol metabolismat lysine residues 156 and 158, thereby inducing cholesterol synthesis and subsequently facilitating CRC cell proliferation and metastasis (71)

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[33] The rising publicity around Hong Kong following the 1997 handover sparked a re-emergence in the public interest of Kowloon Walled City and its disappearance

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TT, TY and YBL: Project administration, Resources, Software