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When contamination is adequately controlled, non-Lactobacillus-dominant profiles have been associated with increased risk of implantation failure and may contribute to the inflammatory endometrial phenotypes observed in a subset of RIF and RM patients [380]

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Luminal oxygen tension and metabolic processes Oxygen tension markedly affects intestinal metabolic, physiological, molecular, and cellular activities, with hypoxia (decreased oxygen availability) being a critical factor (Fig