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Genomic plasticity in Leishmania is driven by several mechanisms, including mosaic aneuploidya common feature that enables rapid adaptation under stress, with non-random, strain-specific patterns indicating selective pressure (Sterkers et al., 2014

4 Folate (vitamin B9) deficiency is also common in those with MTHFR

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An ADME study was also conducted, and the new compounds demonstrated promising efficacy as emerging oral anti-inflammatory drugs