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The dual mechanism is why Eli Lilly positions tirzepatide as a distinct therapeutic option and why some patients specifically need it rather than a single-agonist alternative

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While not universally experienced, tiredness can occur through several mechanismsincluding reduced caloric intake, gastrointestinal symptoms, and rapid metabolic changes

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as a result, surfactant production decreases markedly, which in turn causes alveolar fluid accumulation leading to alveolar collapse and ARDS (Matthay and Zemans, 2011