Acknowledgments The work described in this paper was supported in part by the National Institutes of Health (HL-52233, HL-48743, and NS-10828), the American Heart Association Bugher Foundation Award, and the Deutsche Forschungsgesellschaft
Computational models of complex Ca 2+ dynamics incorporating store-operated Ca 2+ entry and MAM geometry further underscore the nonlinear behavior of this system and its sensitivity to small changes in channel density, ER store content, or mitochondrial buffering capacity ( 2+ transfer and mitochondrial Ca 2+ overload are early pathogenic events, whereas oxidative stress, inflammatory activation, and impaired clearance of damaged mitochondria contribute mainly to propagation and amplification of acinar cell injury
Secure, sealed vial for stability
Symptoms often begin after an event, such as physical trauma, surgery, infection, or significant psychological stress
The Dosage Amount More is not always better
Two MDHA molecules can react with each other to form one molecule each of AsA or DHA, a two-electron oxidized form of AsA