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This chronic immune stimulation contributes to systemic inflammation, immune exhaustion, and the ebbing-and-flowing symptom pattern many long COVID patients describe, where they feel marginally better and then crash again

Toll-like receptors (TLRs) are responsible for activating the innate immune system via sensing microbial particles such as flagellin

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Metal-Mediated Signaling: Delivers bioavailable Cu to copper-dependent enzymes and pathways (e.g., lysyl oxidase family) that participate in cross-linking and tissue architecture

Since then numerous patients have been treated with high dose vitamin B12 worldwide