Historically, addressing weight and addiction have been treated as separate clinical problems a patient might see an endocrinologist for metabolic syndrome and an addiction specialist for alcohol dependence, with little coordination between them
The slowed gastric emptying from semaglutide could theoretically alter when and how much of the mycophenolate gets absorbed
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Fat-selective weight loss would be an additional advantage, as the STEP-1 (NCT03548935) trial demonstrated that once-weekly semaglutide 2.4 mg resulted in 3.4 kg (7.5 lb) more loss in lean body mass compared to placebo
These findings emphasize the necessity for continuous, long-term monitoring of patients receiving combination therapy with GLP-1 receptor agonists and metformin, regardless of treatment duration, to ensure timely identification and management of potential adverse events
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