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Study Design and Population OASIS 4 was a randomized, double-blind, placebo-controlled trial conducted across 22 sites in Canada, Germany, Poland, and the United States

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While the exact way phentermine reduces appetite remains unclear, the drug is thought to act by increasing neurotransmitter levels in your brain ( Neurotransmitters the chemicals norepinephrine, serotonin, and dopamineare are your bodys chemical messengers ( When your levels of these three chemicals increase, your feeling of hunger decreases

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