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This explains why intracellular oxidation kinetics for roGFP2 fusion constructs with glutaredoxin mutants showed excellent correlation with the second order rate constants of the oxidative half-reaction from in vitro experiments 15,26,34,35

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This complex interaction regulates hepatic metabolism and modulates brain function, thereby playing a pivotal role in maintaining systemic metabolic homeostasis and contributing to the pathophysiology of various diseases (Figure.1)