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The multivariate analysis reported that body weight at 12 months was 8.2 kg higher in the liraglutide group than placebo (8.23 kg, 95%CI: 1.6, 14.9 kg, p = 0.020, Supplementary Table 6.4)

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Mechanistically, multi-omics analyses of cardiac and hepatic tissues revealed that semaglutide exerted these benefits by improving cardiac metabolism, interfering with pro-fibrotic and pro-hypertrophic signals, and by reducing systemic inflammation