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2) reduce the dose of oral minoxidil to 1.25 mg or 1.875 mg and add spironolactone 50-100 mg once daily if there are no contraindications and the patient accepts the potential side effects

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However, when the cell detects an apoptotic stimulus, such as DNA damage or metabolic stress, the intrinsic apoptotic pathway is triggered and mitochondrial cytochrome c is released into the cytosol (Kroemer et al., 2007)

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