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[18] In addition, choline can donate methyl groups to support methionine regeneration, possibly contributing to their synergistic lipotropic effects

Metformin was also demonstrated to alter mitochondrial function in CRC, specifically increasing mitochondrial mass in SW837 cells and altering ROS production and mitochondrial membrane potential in SW837 and HCT116 cells, supporting previous studies in models of prostate, endometrial, pancreatic, lung, breast and CRC (5054)

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