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A multicenter trial of 390 patients with diabetes mellitus receiving insulin therapy who were randomized to receive metformin, 850 mg three times daily, or placebo assessed the risk of vitamin B 12 deficiency and low vitamin B 12 levels over four years

The mechanistic plausibility is clear: if a compound supports angiogenesis and collagen synthesis in wound environments, the theoretical rationale for faster tissue repair is sound

And they work

Many insights come from studies exploring how metalorganic complexes interact with cellshow they enter them, what redox states they adopt, and how they influence signaling pathways

This is valuable for educational discussions about trial design, dosing ranges, and peptide behaviour

Bioorganicheskaia Khimiia (in Russian)