However, their specific components and mechanism of action are still unclear
Unlike classical T1D with almost only hyperglycemia, T2D is just one component of MDS, and is often accompanied by other components of MDS, such as overweight/obesity (preobesity might be a more appropriate term instead of overweight since obesity is not determined only by weight), metabolic dysfunction associated steatotic liver disease (MASLD), dyslipidemia
The production of free radicals by glucose oxidation is considered as central origin of ROS
Frias JP, Davies MJ, Rosenstock J, Perez Manghi FC, Fernandez Lando L, Bergman BK, et al
Heart failure in the patient with diabetes: Epidemiology, aetiology, prognosis, therapy and the effect of glucose-lowering medications
Here the G6PD prevents the oxidative damage due to the generation of species reactive to oxygen from the adult hemoglobin 14,15