Chapters: 00:00 Intro & Mixing Peptides Debate 04:44 Peptides for Recovery & Inflammation 09:31 Autoimmune Disorders Explained 15:30 Thymalin, TA1 & Immune Function 18:38 LL-37, VIP & Pathogen Response 23:13 Crohns, Hashimotos & Gut Health 27:06 BPC-157, Angiogenesis & Healing 32:19 Surgery Recovery & Peptide Protocols 33:01 Vitiligo, Psoriasis & Skin Healing 35:35 Folliculitis, Leaky Gut & Carnivore 41:10 Toxins, Sauna & Detoxification 46:04 GLP-1s, Inflammation & Neuroprotection 52:04 Estrogen, TRT & Bloodwork Optimization 56:44 SS-31, MOTS-C & Neuropathy Recovery We cover: What's happening in autoimmune disorders Body attacks itself thyroid in Hashimoto's, gut in Crohn's, skin in psoriasis 80% of diagnosed autoimmune disorders occur in women Root cause is almost always the gut fix the gut, everything follows Antibiotics, processed food, seed oils, stress, and poor sleep are the biggest culprits Master Autoimmune Protocol (Psoriasis, Lupus, Lyme, MS) Thymalin: re-educates immune system the marathon (510mg, 10 days straight) Thymosin Alpha-1 (TA-1): quick sprint to boost T cells (1.5mg, 3x/week, 68 weeks) Run both together LL-37: penetrates biofilm, dumps pathogens 125mcg for 50 days Don't start LL-37 too early triggers Herxheimer reaction VIP: cleans up after LL-37 start 100mcg 3x/week, build to 200mcg Always anchor with KPV + BPC-157 Crohn's & Colitis Protocol KPV + BPC-157 orally first straight to the source Add Thymalin + TA-1 simultaneously Bring in LL-37 if not responding, follow with VIP, then MoTC Support stack: Glutathione + NAC + L-Glutamine Hashimoto's Protocol Same immune foundation: TA-1, Thymalin, KPV, BPC-157 + MoTC Once markers trend down add GH peptides (Tesmorelin or CJC + Ipamorelin) for muscle wasting Monitor insulin, thyroid levels, and autoimmune markers before adding GH axis SS-31 vs MoTC SS-31 first: repairs the engine MoTC second: press the gas SS-31 also powerful for kidney repair, neuropathy, and heart health ARA-290 Derivative of EPO no blood doping effects Exceptional for neuropathy and nerve regeneration Pairs well with SS-31 GLP-1 Optimization Reta: Paul hasn't seen anyone need to exceed 8mg Plateaued on tirzepatide or sema
The design and protocol rationale were laid out in detail by Giblin et al
Weickert et al.74 found that ingestion of insoluble fibers significantly accelerated early insulin response, whereas GLP-1 postprandial levels were not influenced
Pfizer, after discontinuing its initial danuglipron candidate due to safety concerns in April 2025, re-entered the race through a $10 billion acquisition of clinical-stage biotech Metsera in November 2025, securing a next-generation obesity pipeline [43]
Hims and Hers offer similar compounded GLP-1 pricing but require prepaid commitments that limit flexibility
In a double blinded randomised study, daily injections of semaglutide (0.4 mg) in obese patients resulted in an average of 14% decrease in body weight, over placebo, after a year
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