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Patients with intolerable early side effects from rapid dosing often reduce or stop treatment, resulting in lower total weight loss at 12 months compared to those who titrate gradually

Animals developed persistent esophagitis with hemorrhagic lesions, thinned epithelium, and chronically reduced sphincter pressures lasting up to 20 months

GLP-1RAs demonstrated a favorable safety profile, with no meaningful increase in severe hypoglycemia or acute pancreatitis observed across trials

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(1) Observed mean value from Week 0 to Week 72, and (2) least squares mean standard error at Week 72 hybrid imputation (HI)

After incubation of the supernatants with Escherichia coli NO 3 reductase (37, 30 min), 1 ml of Griess reagent (0.5% naphthylenediamine dihydrochloride, 5% sulfonilamide, 25% H 3 PO 4 ) was added