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The effectiveness of glutathione suppositories can vary based on individual patient factors and the specific disease state being treated

Chung YC, Kruyer A, Yao Y, Feierman E, Richards A, Strickland S, Norris EH (2016) Hyperhomocysteinemia exacerbates Alzheimers disease pathology by way of the -amyloid fibrinogen interaction

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But insulin dose reduction needs to be done carefully and gradually, with close CGM monitoring, to avoid either hypoglycemia (from too much insulin relative to your new needs) or hyperglycemia (from reducing too aggressively)

doi: 10.1038/s41598-022-22034-1

And the UTIs and the dementia and the dont get close to HRT, to any kind of hormone therapy