Tirzepatide acts through GIP and GLP-1 receptors
The effects of the leptin-GLP-1 interaction may be governed by intracellular signaling pathways, including those involving phosphorylated STAT3 and PTP1B
Zepbound: Zepbound side effects According to the FDA, common Zepbound side effects include: Nausea Vomiting Diarrhea Constipation Abdominal pain Indigestion Injection site reaction Hair loss Fatigue Though rare, serious side effects include: Pancreatitis Low blood sugar Kidney injury Gallbladder disease Severe gastrointestinal reactions Worsening of diabetic retinopathy Allergic reactions Thyroid tumors Suicidal behavior and ideation Visit the manufacturers site for a full list of Zepbound side effects
In the SURMOUNT-1 trial, patients lost an average of 22.5% of body weight over 72 weeks
The injection route delivers medication directly into subcutaneous tissue, bypassing digestive processes that slow oral medications by 3060 minutes
Around the same time, Tirzepatide was listed as the first peptide approved for use to treat sleep apnea