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Figure 1 4.1 Macrophage fatty acid metabolic disorders potentiate MSU crystal-induced inflammation Numerous studies have shown that the inflammatory factor interleukin-1 beta (IL-1) is essential for MSU crystal-driven inflammation and is released, in place of infiltrating neutrophils or monocytes, from the resident macrophages in the initial stage of GA (38, 39)

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The rest of the atoms within C1-27 interact with the H-site causing rearrangement of several side chains and a 1 shift in the 4b helix (residues 122132) with respect to the GSTO1-GSH structure (1EEM) (Fig