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For some, daily use may be fine, but others might need to limit it to avoid irritation or dryness. Using kojic acid soaps can result in potential side effects, such as contact dermatitis, a condition in which the skin becomes inflamed or irritated as a result of direct contact with a substance

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conducted a 12-week facial study on 67 women and reported that GHK-Cu cream applied twice daily improved aged skin appearance, increased thickness, reduced wrinkles and strongly stimulated dermal keratinocyte proliferation as determined by histological analysis of biopsies

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LPO has also been described following metHb binding to the membrane, suggesting that this linkage favors LPO [37]