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The chromatographic column can be a C 18 chromatographic column (Kromasil-C 18 , 30mm*250mm, Hanbang Technology Chromatography Co., Ltd.), and the samples are loaded in multiple times, and the effluents of the target peaks are collected respectively

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Overall, our work demonstrates a key signaling interplay between DA and NE in - and -cells as a novel regulatory pathway for pancreatic hormone release and offers the promise of new therapeutic approaches to treat the dysfunctional secretion of insulin and glucagon by targeting peripheral catecholamine receptors

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