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Globally, B12 deficiency affects a significant portion of the population, ranging from 6% in some groups to as high as 20% in older adults

Last reviewed: October 2025

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AMPK signaling pathway Adenosine monophosphate -activated protein kinase (AMPK) is a key regulator of ATP homeostasis and exerts dual pro- and anti-ferroptotic effects depending on its substrates

HW TIPS TO MINIMIZE GI SIDE EFFECTS One or more gastrointestinal (GI) side effects are observed in roughly 10% to 50% of people who take one of these weight management medications.1,2 From nausea and vomiting to acid reflux, bloating, stomach cramps, diarrhea, and/or constipation, patients can minimize GI side effects with a start low, go slow approach, starting with the lowest dose and titrating as recommended (see table Currently FDA-Approved Mono and Dual Agonists)