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Regulatory agencies have warned about potential toxicity to the liver, kidneys, and nervous system

Factors such as solubility, bioavailability, biological half-life, route of administration, product shelf life, as well as other pharmacological considerations are contemplated herein

However, when the investigational drug presents a higher level of risk for example in certain oncology settings, where the compound may be too toxic for healthy subjects the study may involve patients instead

The Src-Caveolin-1-eNOS pathway produces nitric oxide for vasodilation

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