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However, a possible obstacle to this therapy is ghrelins half-life

Poor Diet: A diet lacking in essential nutrients, particularly those needed for glutathione synthesis, can also result in lower glutathione levels

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Recently, despite administration of NAC 600 mg po tid, a sustained increase in GSH concen-trations could not be found in the plasma, bronchoalveolar lavage fluid, or lung tissue of patients with chronic obstructive pulmonary disease