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In this scenario, adipocytemacrophage interactions seem necessary to activate pro-thrombotic responses in people living with obesity

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121,122 Ji et al found that oral administration of TMAO significantly exacerbated demyelination in spontaneously hypertensive rats, with the underlying mechanism possibly related to TMAO-induced pyroptosis of oligodendrocytes and inflammation

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This variability underscores why personalized medical oversight matters when combining semaglutide with a complex medication regimen

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