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Originally investigated for cardiovascular conditions, sildenafil went on to revolutionize the treatment of Erectile Dysfunction (ED) and later became an important therapy for Pulmonary Arterial Hypertension (PAH)

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Eight participants (15%) in each arm discontinued prematurely, leaving 92 who completed 32 weeks

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(13) Additionally, GLP-1 signaling may help suppress pro-inflammatory pathways, reducing the chronic low-grade inflammation associated with both obesity and bone loss

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