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Br J Pharmacol 179(4):659676 Hernandez AF, Green JB, Janmohamed S, DAgostino Sr RB, Granger CB, Jones NP, et al (2018) Albiglutide and cardiovascular outcomes in patients with type 2 diabetes and cardiovascular disease (Harmony Outcomes): a double-blind, randomised placebo-controlled trial

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Peptides with very short half-lives, such as Sermorelin and Tesamorelin, produce sharp, pulsatile signals that mimic physiological release patterns, which is often desirable when studying hypothalamic feedback loops