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Acute pancreatitis typically manifests with severe upper abdominal pain that may radiate to the back, nausea, vomiting, and fever

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Vasoactive Intestinal Polypeptide (VIP) Vasoactive intestinal polypeptide (VIP), a peptide messenger present in the central and peripheral nervous systems, is involved in a number of biological functions [75], including smooth muscle relaxation, regulatory hormone secretion and regulation of the immune response [76,77]