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Alcohol irritates the stomach lining and can trigger or worsen nausea, vomiting, and heartburn in people already managing semaglutide-related GI changes

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the drug nudges the wire indirectly by changing gastric volume and nerve signaling

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Rectal suppositories bypass the gastrointestinal tract, which can be advantageous in situations where the oral route is compromised or when a rapid onset of action is desired