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GLP-1s may not be suitable for people who: Have a history of pancreatitis Have certain thyroid conditions (e.g., medullary thyroid cancer) Are pregnant or breastfeeding (depending on the specific medication) Have severe gastrointestinal conditions, like gastroparesis GLP-1 receptor agonists, including Tirzepatide, have been shown to lead to significant weight loss, with many people losing 10-15% of their body weight over time

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Lancet (1978) 1:7858

The neonatal Fc receptor (FcRn) plays a key role in regulating albumin homeostasis 33 , and therefore, the FcRn-albumin relationship should be considered when designing albumin-based fusion proteins